Research consultant

Targeting the Angiopoietin/Tie2 pathway to achieve vascular integrity in retinal vascular disease


Supplier’s declaration

This continuing medical education activity is provided by

Statement of support

This activity is supported by a scholarship from Genentech, a member of the Roche group.

activity Descrition

The need to identify alternative molecular targets for the management of retinal vascular disease has been highlighted by the proportion of patients who have a suboptimal response or no response to intravitreal anti-vascular endothelial growth factor therapies. (VEGF). Other pathways that have demonstrated involvement in abnormal angiogenesis and increased vessel permeability in the eye, such as the angiopoietin/Tie2 pathway, are attractive targets. In this CME activity, experts in the field examine the role of the angiopoietin/Tie2 pathway in retinal and choroidal vascular disease and provide updates on the latest clinical evidence regarding the safety and efficacy of injectable therapies that target the angiopoietin/Tie2 pathway in these patients.

Target audience

The target audience for this activity is retinal specialists and other healthcare professionals involved in the care of patients with retinal and choroidal vascular diseases.

Learning objectives

Upon successful completion of this activity, participants should be better able to:

  • Describe how the angiopoietin/Tie2 pathway is a regulator of vascular development and maintenance, homeostasis, and inflammation in retinal and choroidal vascular disease.
  • To assess emerging evidence regarding the safety and efficacy of emerging injectable therapies that act on the angiopoietin/Tie2 pathway and may improve visual outcomes in patients with retinal and choroidal vascular disease.

activity chair

Arshad M. Khanani, MD, MA
Managing partner
Director of Clinical Research
Fellowships Director
Sierra Eye Associates
Clinical Associate Professor
University of Nevada
Reno, Nevada


Jennifer I. Lim, MD
Professor of ophthalmology
Marion H. Schenk Chair and Professor of Ophthalmology
Retina Service Director
Vice President for Diversity and Inclusion
Department of Ophthalmology
University of Illinois Chicago Medical School
Chicago, IL

Michael A. Singer, MD
Director of Clinical Research
Medical Center Ophthalmology Associates
clinical professor
University of Texas Health Sciences Center
San Antonio, TX


Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP


Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit designation

Vindico Medical Education designates this material durable for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the assessment component, enables the learner to meet the lifelong learning and self-assessment requirements of the Continuing Certification Program. American Board of Ophthalmology. It is the responsibility of the CME activity provider to submit learner completion information to ACCME for the purpose of granting credit.

If successful, learners who register by providing their ABO ID and date of birth (MM/DD) will earn Continuing Certification Credits equal to the number of CME Credits claimed for the activity.

This durable material is approved for 1 year from the original publication date, May 25, 2022 through May 24, 2023.

How to participate in this activity and get a CME credit

To participate in this CME activity, you must read the objectives, answer the survey and pre-test questions, view the content, and complete the post-test and assessment. Provide only one (1) correct answer for each question. A passing score is defined as answering 100% of the post-test questions correctly. Upon receipt of the completed documents, if a satisfactory post-test score is obtained, Vindico Medical Education will issue a AMA PRA Category 1 Credit(s)™ certificate.


Vindico Medical Education adheres to the ACCME Standards of Integrity and Independence for Accredited Continuing Education. Anyone in a position to control the content of a continuing education activity, including faculty, planners, reviewers, or others, is required to disclose all relevant financial relationships with nonqualifying entities (business interests). All relevant conflicts of interest have been mitigated before the start of the activity.

The activity director and faculty report the following relevant financial relationships

Arshad M. Khanani, MD, MA
Consultant: 4DMT, Adverum, Aerpio, Allergan, Apellis, Broadwing Bio, Gemini, Genentech, Graybug, Gyroscope, Iveric Bio, Kato, Kodiak, Novartis, Opthea, Oxurion, PolyPhotonix, Regenxbio, Surrozen
Speaker hired by an ineligible company: Allergan, Genentech, Novartis
Independent Research Contractor: Adverum, Alkahest, Allegro, Allergan, Annexon, Gemini, Genentech, Gyroscope, Iveric Bio, Kodiak, NGM Pharmaceuticals, Novartis, Opthea, Ophthotech, Oxurion, Regenxbio

Jennifer I. Lim, MD
Consultant: Cognition, Genentech/Roche, Iveric Bio, Luxa, Novartis, Opthea, Santen, Unity
Independent Research Contractor: Genentech, Greybug, NGM, Regeneron, Stealth

Michael A. Singer, MD
Advise: Allergan, EyePoint, Genentech, Novartis, Regeneron

The reviewer reports the following relevant financial relationships

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationship to disclose.

Vindico Medical Education staff report the following relevant financial relationships

No relevant financial relationship to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Experimental Use

The public is advised that this continuing medical education activity may contain references to unlabeled uses of products approved by the United States Food and Drug Administration (FDA) or products not approved by the FDA for use in the United States. -United. Faculty members have been informed of their obligation to disclose such use. All activity participants will be notified if any speakers/authors intend to discuss non-FDA approved or investigational use of products/devices.

Copyright statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Phone: 856-994-9400; Fax: 856-384-6680. Printed in USA. © 2022 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. Material presented at or in any of Vindico Medical Education’s continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorses or recommends any techniques, commercial products or manufacturers. Professors/authors may discuss the use of materials and/or products that have not yet been approved by the United States Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or using any product.

Questions about the CME?

Contact us at